The 24-year-old started brightly by taking the first set off the 19th seed on Monday but his lack of match fitness told as, despite frequent treatment from the trainer, he lost the next three to bow out at the first hurdle in a third straight grand slam.
Pliskova, a finalist at last year's US Open who reached the semi-finals at Indian Wells last week, relied on her booming groundstrokes and strong returning to dispatch her American opponent in 59 minutes.
'I think we should have a heat rule, it's not healthy to be out there getting dizzy and stuff and the poor ball kids out there. There should definitely be a heat rule looked at and put into place'
The US Open reached an emotional climax on Sunday as the year's final grand slam paused amid heavy security before the start of the men's singles to remember those who died in the 9/11 attacks 15 years ago.
Marin Cilic and Kei Nishikori will meet in the semi-finals at the Citi Open in Washington on Saturday, their first encounter since the final of last year's US Open.
Rohan Bopanna and Divij Sharan used all their experience to bounce back and enter the men's doubles final of the Asian Games, in Palembang, on Thursday.
Novak Djokovic won his fourth China Open title in five years on Sunday, prevailing 6-3, 6-4 in the final against Rafael Nadal who will replace him as the men's new world number one on Monday.
Madison Keys swept past Wimbledon champion Elena Rybakina 6-2, 6-4 at the Cincinnati Open on Friday, setting up a semi-final clash with Petra Kvitova after the Czech defeated Ajla Tomljanovic.
Serena Williams won her 750th career match to stay on track for her ninth Miami Open title when she beat Zarina Diyas of Kazakhstan 7-5 6-3 in the third round in Florida on Saturday. The world number one improved her career record to 750-125, seventh on the all-time list and just three match wins behind Lindsay Davenport's 753. Martina Navratilova sits atop the all-time list with 1,442 wins. The 34-year-old Williams will meet Russian Svetlana Kuznetsova in the fourth round. The 15th seed defeated France's Caroline Garcia 4-6 6-2 7-6(6). Unlike the last time they met, when Williams required 54 minutes and Diyas won just two games, the 22-year-old Kazak gave the American some trouble in the heat and humidity of Miami.
World number eight Williams, who captured the first of her six US Open titles two years before her 17-year-old opponent was born, spent the first half of the match trying to find her rhythm but when she did she was off to the races.
Eugenie Bouchard slumped to a first-round defeat at the US Open on Tuesday but the Canadian might yet leave Flushing Meadows a big winner with her lawsuit against the Grand Slam and United States Tennis Association still to hit the courts.
Awesome images from the world of Sport 2018.
Roger Federer launched his bid for an 18th grand slam title with a workmanlike 6-3, 6-4, 7-6 (4) win over Marinko Matosevic to ease into the second round of the US Open on Tuesday, with NBA great Michael Jordan leading the cheering.
"It's been an amazing year so far," said the 25-year-old Nishikori, who will move up to fourth from fifth in the world rankings. "I've had some good Grand Slams, too."
Leylah Fernandez's storybook US Open continued with yet another upset on Thursday, as the Canadian teenager shocked second seed Aryna Sabalenka 7-6(3), 4-6, 6-4 to reach her first Grand Slam final.
World number one Novak Djokovic and number two Rafa Nadal set up a mouth-watering men's singles final at the US Open with victories in the semi-finals at Flushing Meadows on Saturday.
Former world number one Caroline Wozniacki eased into the semi-finals of the US Open on Tuesday with a ruthless 6-0, 6-2 win over wounded Latvian Anastasija Sevastova.
Entering their third Grand Slam final of the year, Leander Paes and Martina Hingis continued their golden run as mixed doubles pair as they beat Bethanie Mattek-Sands and Sam Querrey 6-4, 3-6, 10-7 to win the U.S. Open Mixed Doubles title at the Louis Armstrong stadium on Friday.
Serena Williams will be wary of another semi-final slip-up when she takes to the Arthur Ashe Stadium court on Thursday to face 10th seed Karolina Pliskova for a spot in the US Open final.
Bethanie Mattek-Sands of the US and Czech Lucie Safarova fought back from the brink of defeat to steal the US Open women's doubles title, 2-6, 7-6(5), 6-4 over the French top seed partnership of Caroline Garcia and Kristina Mladenovic on Sunday.
The German sixth seed, who has not won a title since winning at Flushing Meadows last year, never got into the match against the 2016 WTA newcomer of the year.
World number one Novak Djokovic continued his rich vein of form as he brushed aside French opponent Jo-Wilfried Tsonga in straight sets to clinch the Shanghai Masters title on Sunday.
Chasing a sixth US Open title, Federer needed just one hour and 46 minutes under a closed roof at Arthur Ashe Stadium to put away the 31st seed Lopez, leaving plenty in the tank after being forced to go the distance in his opening two matches.
Dolgopolov, who advanced to the 2nd round of the US Open on Wednesday, said he could not remember ever being approached to fix a match.
Williams had signalled her intention to retire in a Vogue article in early August, saying she was "evolving away from tennis" but never confirming the U.S. Open as her final event.
A summary of Wednesday's action at the US Open.
Fifth seed Simona Halep narrowly avoided a third-round upset with a 6-1, 2-6, 6-4 win over Hungary's Timea Babos on Saturday to keep her US Open title hopes alive.
After a flawless first set from Mertens the tide turned in Andreescu's direction in the second when she fired a cross-court forehand winner to break the Belgian at love and take a 4-2 lead.
Prajnesh Gunneswaran got a taste of high-level tennis in his first-round exit from the US Open, losing to world number five Daniil Medvedev in 84 minutes, in New York, on Monday.
IMAGES from the matches played at Miami Miasters in Key Biscayne, Florida, on Wednesday
Images from the US Open final played at Flushing Meadows on Sunday
'It was beautifully played by an American band.'
A summary of Wednesday's action at the US Open.
IMAGES from Day 9 of the US Open matches played on Tuesday
New York City Police Commissioner William Bratton apologised on Thursday to former US tennis star James Blake, who was arrested after being wrongly identified as a suspect in a fraud ring and said he is concerned over how much force is used.
Roger Federer returned from a month-long layoff with a 6-4, 6-4 second round victory over Roberto Bautista Agut on Tuesday at the Western and Southern Open in Cincinnati.
Five-times champion Roger Federer reached his first US Open final in six years as he raced past fellow Swiss Stan Wawrinka 6-4, 6-3, 6-1 at Flushing Meadows in the semi-finals on Friday.
With Roger Federer and 2018 champion Novak Djokovic having already made exits, Nadal's path to a fourth US Open trophy has been cleared of familiar hurdles.
In the decider, Berrettini broke twice for a 4-2 lead but a rejuvenated Monfils dug deep and raced around the court to fight off three match points to force a final-set tiebreak. But it was Berrettini who leaned on his powerful serve to prevail and become the fourth Italian man to reach a Grand Slam semi-final in the Open Era.
A summary of Wednesday's action at the US Open on Day 3.
